Impact of using triclosan-antibacterial sutures on incidence of surgical site infection

Am J Surg. 2011 Aug;202(2):133-8. doi: 10.1016/j.amjsurg.2010.06.011. Epub 2011 May 19.

Abstract

Background: Surgical site infection is a common complication of surgery. Its morbidities range from delayed healing to systemic sepsis. It has impact on the economy and health care resources.

Methods: This study was a prospective, randomized, double-blinded, controlled multicenter study aimed to compare triclosan-coated polyglactin 910 sutures with polyglactin 910 sutures for the reduction of surgical site infections. This article details the results from the Cairo University center. A total of 450 patients who had undergone different surgical procedures were enrolled; 230 were enrolled in the study group and 220 were enrolled in the control group.

Results: The study group and the control group were comparable regarding risk factors for surgical site infection. Surgical site infection incidence was 7% in the study group and 15% in the control group (P = .011). The mean extended stay as a result of infection was 3.71 days, with an average cost $91 US per day.

Conclusions: Use of the triclosan-coated polyglactin 910 antimicrobial suture lead to reduction of surgical site infection and has an impact on saving health care resources. The triclosan-coated polyglactin 910 antimicrobial suture could save $1,517,727 yearly in this single center.

Publication types

  • Randomized Controlled Trial

MeSH terms

  • Adult
  • Anti-Bacterial Agents / therapeutic use*
  • Anti-Infective Agents, Local / therapeutic use*
  • Coated Materials, Biocompatible / therapeutic use*
  • Dioxanes
  • Double-Blind Method
  • Egypt / epidemiology
  • Female
  • Hospital Costs
  • Hospitals, University / statistics & numerical data
  • Humans
  • Incidence
  • Length of Stay* / economics
  • Length of Stay* / statistics & numerical data
  • Male
  • Middle Aged
  • Polyesters
  • Polyglactin 910
  • Prospective Studies
  • Risk Factors
  • Surgical Wound Infection / economics
  • Surgical Wound Infection / epidemiology
  • Surgical Wound Infection / prevention & control*
  • Sutures* / economics
  • Triclosan / therapeutic use*
  • Wound Healing

Substances

  • Anti-Bacterial Agents
  • Anti-Infective Agents, Local
  • Coated Materials, Biocompatible
  • Dioxanes
  • Polyesters
  • Polyglactin 910
  • glycolide E-caprolactone copolymer
  • Triclosan