A newborn with Pierre Robin sequence after preconceptional mitoxantrone exposure of a female with multiple sclerosis

J Neurol Sci. 2011 Aug 15;307(1-2):164-5. doi: 10.1016/j.jns.2011.05.003. Epub 2011 May 20.


Multiple sclerosis is a common disease of young adults in which accidental and unplanned pregnancies under disease modifying or immunosuppressive therapies may occur. The experience with mitoxantrone (MIX) especially in the first trimenon is very limited, until now only one case of a pregnant woman with MS who was exposed to MIX in early pregnancy and delivered a growth restricted but healthy child was published. We report a case of a secondary progressive MS patient who was exposed periconceptionally to MIX and delivered a child with Pierre Robin Sequence (PRS), a syndrome with the main features of glossoptosis, micrognathia, and palate clefts. PRS is a very rare defect and therefore a causal relation with MIX seems possible.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Abnormalities, Drug-Induced / metabolism*
  • Abnormalities, Drug-Induced / pathology
  • Adult
  • Antiemetics / therapeutic use
  • Antineoplastic Agents / adverse effects
  • Female
  • Humans
  • Infant, Newborn
  • Male
  • Mitoxantrone / adverse effects*
  • Multiple Sclerosis, Chronic Progressive / drug therapy*
  • Multiple Sclerosis, Chronic Progressive / metabolism
  • Ondansetron / therapeutic use
  • Pierre Robin Syndrome / chemically induced*
  • Pierre Robin Syndrome / metabolism*
  • Pierre Robin Syndrome / pathology
  • Preconception Injuries*
  • Pregnancy
  • Pregnancy, Unplanned / drug effects
  • Prenatal Exposure Delayed Effects / chemically induced*
  • Prenatal Exposure Delayed Effects / metabolism*
  • Prenatal Exposure Delayed Effects / pathology


  • Antiemetics
  • Antineoplastic Agents
  • Ondansetron
  • Mitoxantrone