Comparison of active sites of some microbial ribonucleases: structural basis for guanylic specificity

Trends Biochem Sci. 1990 Apr;15(4):158-62. doi: 10.1016/0968-0004(90)90217-y.

Abstract

Crystallographic studies of enzymes complexed with suitable ligands are an important tool to aid our understanding of biological catalysis. To this goal, a contribution is made by analysing structures of complexes formed by three guanyl-specific ribonucleases with guanosine 3'-monophosphate.

Publication types

  • Comparative Study
  • Review

MeSH terms

  • Amino Acid Sequence
  • Bacteria / enzymology
  • Binding Sites
  • Fungi / enzymology
  • Guanine Nucleotides / metabolism*
  • Guanosine Monophosphate / metabolism*
  • Models, Molecular
  • Molecular Sequence Data
  • Ribonucleases / metabolism*
  • Sequence Homology, Nucleic Acid
  • Substrate Specificity

Substances

  • Guanine Nucleotides
  • Guanosine Monophosphate
  • Ribonucleases