DNA polymerases and repair synthesis in NER in human cells

DNA Repair (Amst). 2011 Jul 15;10(7):730-3. doi: 10.1016/j.dnarep.2011.04.023. Epub 2011 May 20.


The late steps of nucleotide excision repair, following incisions to remove the damaged section of DNA, comprise repair synthesis and ligation. In vitro and in vivo studies have shown the size of the repaired patch to be about 30 nucleotides. In vitro studies implicated the replicative polymerases in repair synthesis, but recent in vivo data have shown that several DNA polymerases and ligases are involved in these steps in human cells.

Publication types

  • Review

MeSH terms

  • DNA / genetics*
  • DNA / metabolism
  • DNA / radiation effects
  • DNA Damage*
  • DNA Ligases / metabolism
  • DNA Repair*
  • DNA Replication
  • DNA-Directed DNA Polymerase / metabolism*
  • Humans
  • Proliferating Cell Nuclear Antigen / genetics
  • Proliferating Cell Nuclear Antigen / metabolism
  • Ultraviolet Rays


  • Proliferating Cell Nuclear Antigen
  • DNA
  • DNA-Directed DNA Polymerase
  • DNA Ligases