Reference ranges for serum S100B protein during the first three years of life

Clin Biochem. 2011 Jul;44(10-11):927-9. doi: 10.1016/j.clinbiochem.2011.05.004. Epub 2011 May 13.


Objective: Clinical and diagnostic management of traumatic brain injuries is problematic in young children. To facilitate this management, we describe blood reference ranges for the well established biomarker S100B in children younger than 3 years.

Design and methods: Serum S100B concentrations were determined by electro-chemiluminescence immunoassay in a population of 186 healthy children aged 0-3 years.

Results: Four age groups emerged, i.e. 0-3, 4-9, 10-24 and 25-36 months. We also found an interesting inverse correlation with head circumference.

Conclusion: This study provides useful serum S100B values from the largest cohort of healthy children aged 0-3 years old.

MeSH terms

  • Adolescent
  • Child
  • Female
  • Humans
  • Infant
  • Infant, Newborn
  • Male
  • Nerve Growth Factors / blood*
  • Reference Values
  • Regression Analysis
  • S100 Calcium Binding Protein beta Subunit
  • S100 Proteins / blood*


  • Nerve Growth Factors
  • S100 Calcium Binding Protein beta Subunit
  • S100 Proteins
  • S100B protein, human