Abstract
The ethanolic extract from stems of a Thai medicinal plant, Alstonia macrophylla Wall. ex G. Don (Apocynaceae) showed a significant inhibitory effect on acetylcholinesterase (AChE) determined by using Ellman assay. Four compounds i.e., a bisindole alkaloid, macralstonine (1), a new bisindole alkaloid, thungfaine (2), a secoiridoid glycoside, sweroside (3) and a new secoiridoid glycoside, naresuanoside (4) were isolated. Compound 4 showed moderate AChE and butyrylcholinesterase (BChE) inhibitory effects. Interestingly, compound 4 inhibited cell growth on human androgen-sensitive prostate cancer cell line (LNCaP) but no effect on viability of human foreskin fibroblast cells (HF).
Copyright © 2011 Elsevier B.V. All rights reserved.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Acetylcholinesterase / drug effects
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Alstonia / chemistry*
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Animals
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Butyrylcholinesterase / drug effects
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Cell Line, Tumor
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Cell Proliferation / drug effects
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Cells, Cultured
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Electrophorus
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Fibroblasts / drug effects
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Foreskin / cytology
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Foreskin / drug effects
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Glycosides / chemistry*
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Glycosides / isolation & purification
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Glycosides / pharmacology
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Horses
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Humans
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Indole Alkaloids / chemistry*
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Indole Alkaloids / isolation & purification
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Indole Alkaloids / pharmacology
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Inhibitory Concentration 50
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Iridoid Glucosides / chemistry*
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Iridoid Glucosides / isolation & purification
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Iridoid Glucosides / pharmacology
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Iridoids / chemistry*
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Iridoids / isolation & purification
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Iridoids / pharmacology
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Male
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Medicine, East Asian Traditional
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Plant Extracts / chemistry*
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Plant Stems / chemistry
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Plants, Medicinal / chemistry
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Thailand
Substances
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Glycosides
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Indole Alkaloids
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Iridoid Glucosides
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Iridoids
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Plant Extracts
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Acetylcholinesterase
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Butyrylcholinesterase
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sweroside