Personality traits of aggression-submissiveness and perfectionism associate with ABO blood groups through catecholamine activities

Med Hypotheses. 2011 Aug;77(2):294-300. doi: 10.1016/j.mehy.2011.04.039. Epub 2011 May 23.


Personality trait research has shown associations with many genes, prominently those of the catecholamine metabolism such as dopamine beta hydroxylase (DBH), catechol-O-methyltransferase (COMT), and monoamine oxidase A (MAOA). Because DBH gene is in linkage disequilibrium with ABO gene, there is reason to think that other catecholamine genes using the same substrate as DBH may also have associations with ABO blood groups, and this paper demonstrates how this may be so. Reasons include similarities in hapmap population frequency distributions, similarities in illness risks between ABO blood groups and DBH activities as well as between ABO blood groups and COMT activities and between ABO blood groups and MAOA activities. If ABO blood groups can be demonstrated to associate with all these catecholamine genes, then the catecholamine personality trait research can be applied to ABO blood groups and tested for confirmation. ABO blood typing is widely available and affords ability to test this hypothesis and thus confirm the possible joint association of personality traits of aggression-submissiveness and perfectionism to catecholamine genes and to ABO blood groups. Clinical applications and implications are discussed.

MeSH terms

  • ABO Blood-Group System / genetics*
  • Aggression
  • Catechol O-Methyltransferase / genetics*
  • Catechol O-Methyltransferase / metabolism
  • Catecholamines / metabolism*
  • Dopamine beta-Hydroxylase / genetics*
  • Dopamine beta-Hydroxylase / metabolism
  • Genetic Association Studies
  • Humans
  • Monoamine Oxidase / genetics*
  • Monoamine Oxidase / metabolism
  • Personality / genetics*


  • ABO Blood-Group System
  • Catecholamines
  • Dopamine beta-Hydroxylase
  • Monoamine Oxidase
  • Catechol O-Methyltransferase