Abstract
This study investigated the effects of allitridin on acute and chronic mouse cytomegalovirus (MCMV) infections in vivo. The results demonstrated that allitridin reduced the titers of MCMV in salivary glands, and reductions in viral loads were confirmed by determining viral DNA and RNA levels in susceptible organs during the acute infection phase. Although allitridin did not eliminate MCMV, treatment reduced viral levels and facilitated healing of pathologic lesions in organs, particularly during the chronic infection phase. The results presented in this report suggest that allitridin could act as an effective agent against MCMV infections in vivo.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Acute Disease / therapy
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Allyl Compounds / pharmacology*
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Animals
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Antiviral Agents / pharmacology*
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Chronic Disease / therapy
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Cytomegalovirus / drug effects
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Cytomegalovirus / physiology
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Cytomegalovirus Infections / drug therapy
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Cytomegalovirus Infections / virology*
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Disease Models, Animal
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Female
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Herpesviridae Infections / drug therapy
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Herpesviridae Infections / virology*
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Humans
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Mice
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Mice, Inbred BALB C
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Muromegalovirus / drug effects*
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Muromegalovirus / physiology
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Salivary Glands / virology
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Sulfides / pharmacology*
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Viral Load / drug effects
Substances
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Allyl Compounds
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Antiviral Agents
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Sulfides
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diallyl trisulfide