Percutaneous edge-to-edge MitraClip therapy in the management of mitral regurgitation

Eur Heart J. 2011 Oct;32(19):2350-7. doi: 10.1093/eurheartj/ehr101. Epub 2011 May 23.


MitraClip therapy consists of percutaneous edge-to-edge coaptation of the mitral leaflets that is analogous to the surgical Alfieri technique. The safety profile of the MitraClip device is favourable, and survival outcomes in high-surgical-risk patients are superior to historical controls. However, questions remain regarding long-term efficacy and durability. In the U.S.A., the MitraClip device has been studied in a safety and feasibility trial, a randomized pivotal trial against surgical mitral valve repair, and a non-randomized high-risk registry. In addition, the MitraClip now has over 2 years of CE-mark approval and a rapidly expanding clinical experience in Europe, primarily in patients at high risk for surgery. A dedicated multidisciplinary team is necessary, as well as thoughtful patient selection, familiarity with the technical aspects of the procedure including transesophageal ultrasound imaging and post-procedure monitoring. Currently available clinical data are herein reviewed, with emphasis on the current role of MitraClip therapy in relation to existing surgical techniques. Since the MitraClip procedure is still relatively new, continued investigation is required to further define patient populations that will benefit most.

Publication types

  • Review

MeSH terms

  • Aged
  • Cardiac Catheterization / instrumentation
  • Cardiac Catheterization / methods*
  • Heart Valve Prosthesis
  • Heart Valve Prosthesis Implantation / instrumentation
  • Heart Valve Prosthesis Implantation / methods*
  • Humans
  • Mitral Valve Insufficiency / therapy*
  • Mitral Valve*
  • Prospective Studies
  • Prosthesis Design
  • Randomized Controlled Trials as Topic