Inhibition of herpes virus plaquing capacity in human diploid fibroblasts treated with gilvocarcin V plus near UV radiation

Photochem Photobiol. 1990 Apr;51(4):477-9. doi: 10.1111/j.1751-1097.1990.tb01740.x.

Abstract

The capacity of human fibroblasts to support plaque formation by Herpes simplex virus following treatment of the cells with gilvocarcin V, a polyaromatic C-glycoside, plus near ultraviolet radiation (UVA, 320-400 nm) was examined. Gilvocarcin V, plus UVA radiation, effectively inhibited host cell capacity at concentrations five orders of magnitude lower than that of 8-methyoxypsoralen required for capacity inhibition at similar levels of UVA radiation. This result extends the observation of unusual biological potency of UVA-activated gilvocarcins from bacterial cells to human cells.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Aminoglycosides*
  • Anti-Bacterial Agents / pharmacology*
  • Antiviral Agents / pharmacology*
  • Cell Line
  • Coumarins
  • Fibroblasts / drug effects
  • Fibroblasts / radiation effects
  • Glycosides
  • Humans
  • Methoxsalen / pharmacology
  • Simplexvirus / drug effects
  • Simplexvirus / growth & development
  • Simplexvirus / radiation effects*
  • Skin / drug effects
  • Skin / radiation effects
  • Viral Plaque Assay

Substances

  • Aminoglycosides
  • Anti-Bacterial Agents
  • Antiviral Agents
  • Coumarins
  • Glycosides
  • gilvocarcin V
  • Methoxsalen