Breast conserving treatment of Paget's disease

Radiother Oncol. 1990 Apr;17(4):305-9. doi: 10.1016/0167-8140(90)90004-g.


Between 1971 and 1984, 13 patients with histologically proven Paget's disease were treated conservatively with radiotherapy only. The disease was clinically confined to the nipple or surrounding skin, without signs of an underlying tumor. With a mean follow-up of 58.6 months (ranging between 15 and 118 months), and a median follow up of 52 months, no recurrences locally or at distance were seen. Therefore in these selected cases a mastectomy could be avoided. The results with this breast conserving management suggest a place for radiotherapy in the treatment of Paget's disease limited to the nipple.

MeSH terms

  • Aged
  • Breast Neoplasms / radiotherapy*
  • Carcinoma, Intraductal, Noninfiltrating / radiotherapy*
  • Cobalt Radioisotopes / therapeutic use
  • Female
  • Follow-Up Studies
  • Humans
  • Middle Aged
  • Nipples
  • Paget's Disease, Mammary / radiotherapy*
  • Prognosis
  • Radiotherapy Dosage


  • Cobalt Radioisotopes