Electrical conduction block in large nerves: high-frequency current delivery in the nonhuman primate

Muscle Nerve. 2011 Jun;43(6):897-9. doi: 10.1002/mus.22037.


Recent studies have made significant progress toward the clinical implementation of high-frequency conduction block (HFB) of peripheral nerves. However, these studies were performed in small nerves, and questions remain regarding the nature of HFB in large-diameter nerves. This study in nonhuman primates shows reliable conduction block in large-diameter nerves (up to 4.1 mm) with relatively low-threshold current amplitude and only moderate nerve discharge prior to the onset of block.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Electric Conductivity*
  • Electric Stimulation Therapy / methods*
  • Macaca fascicularis
  • Macaca mulatta
  • Male
  • Models, Animal
  • Nerve Block / methods*
  • Neural Conduction / physiology*
  • Peripheral Nerves / pathology
  • Peripheral Nerves / physiopathology*
  • Peripheral Nervous System Diseases / physiopathology
  • Peripheral Nervous System Diseases / therapy*