Solution structure of a human minimembrane protein Ost4, a subunit of the oligosaccharyltransferase complex

Biochem Biophys Res Commun. 2011 Jun 10;409(3):572-6. doi: 10.1016/j.bbrc.2011.05.050. Epub 2011 May 15.


Oligosaccharyltransferase (OST) is a membrane associated enzyme complex that mediates transfer of an oligosaccharide onto asparagine residue of a protein. Human Ost4 is a small membrane protein and belongs to one of the seven subunits of human OST. This study determined the solution structure of human Ost4 in solvent system using NMR spectroscopy. Ost4 was demonstrated that the residues 5-30 adopt an α-helical structure. A kink structure was observed in the transmembrane domain, which may be important for its function.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Sequence
  • Hexosyltransferases / chemistry*
  • Humans
  • Membrane Proteins / chemistry*
  • Molecular Sequence Data
  • Nuclear Magnetic Resonance, Biomolecular
  • Protein Structure, Secondary
  • Protein Structure, Tertiary
  • Protein Subunits / chemistry
  • Solutions


  • Membrane Proteins
  • Protein Subunits
  • Solutions
  • Hexosyltransferases
  • dolichyl-diphosphooligosaccharide - protein glycotransferase