Pathways to inflammation: acne pathophysiology

Eur J Dermatol. 2011 May-Jun;21(3):323-33. doi: 10.1684/ejd.2011.1357.


Acne vulgaris affects as much as 80% of the adolescent population and persists in approximately 3% of middle-aged adults. Only a percentage of these persons seek medical help, however, acne can cause levels of anxiety and depression akin to a chronic illness. A recurring question from patients who seek help from various healthcare professionals - their pharmacist, family doctor or dermatologist, is "why?" They also ask questions about a possible familial link, the impact of their diet and the association with their hormones. The following review aims to link these factors with the end result - inflammation.

Publication types

  • Review

MeSH terms

  • Acne Vulgaris* / etiology
  • Acne Vulgaris* / genetics
  • Acne Vulgaris* / pathology
  • Genetic Predisposition to Disease
  • Humans
  • Inflammation* / complications
  • Inflammation* / genetics
  • Inflammation* / pathology
  • Skin / pathology*