Weaning of neonates from mechanical ventilation by use of nasopharyngeal high-frequency oscillatory ventilation: a preliminary study

J Matern Fetal Neonatal Med. 2012 Apr;25(4):374-8. doi: 10.3109/14767058.2011.580401. Epub 2011 May 26.


Objective: To investigate the feasibility of nasopharyngeal high-frequency oscillatory ventilation (nHFOV) immediately after extubation in difficult-to-wean preterm infants.

Study design: This was an observational study of 20 mechanically ventilated neonates [median (range) birth weight 635 (382-1020)g, median gestational age 25.3 (23.7-27.6) weeks] at high risk for extubation failure. Nine infants had failed at least one previous extubation. Fourteen infants were given hydrocortisone. All 20 infants were extubated into nHFOV, with a mean airway pressure of 8 cmH(2)O, an amplitude of 20 cmH(2)O, and a frequency of 10 Hz.

Results: Infants remained on nHFOV for a median duration of 136.5 (7.0-456.0) h until further weaning to continuous positive airway pressure (n =14) or reintubation (n = 6). Reintubation was performed in 1 of 11 infants who had not experienced any previous extubation, and in five of nine infants who had experienced at least one previous extubation (P < 0.05). PaCO(2) was virtually unchanged from preextubation levels 2 h after extubation, but declined significantly at 32 h from 59.8 (45.0-92.3) mmHg to 50.7 (39.8-74.4) mmHg (P < 0.01). PaCO(2) returned to preextubation levels upon discontinuation of nHFOV.

Conclusion: This small observational study demonstrates that nHFOV can be successfully applied to wean premature infants from ventilator support.

Publication types

  • Clinical Trial

MeSH terms

  • Apgar Score
  • Feasibility Studies
  • Female
  • Fetal Organ Maturity / physiology
  • High-Frequency Ventilation* / methods
  • Humans
  • Infant
  • Infant, Newborn
  • Infant, Newborn, Diseases / therapy*
  • Lung / embryology
  • Male
  • Nasopharynx / physiology
  • Pilot Projects
  • Pregnancy
  • Pregnancy Complications, Infectious / physiopathology
  • Pregnancy Complications, Infectious / rehabilitation
  • Respiration, Artificial / methods
  • Ventilator Weaning / methods*