Natural killer cells in psoriasis

J Innate Immun. 2011;3(4):403-10. doi: 10.1159/000328011. Epub 2011 May 25.


Psoriasis is one of the most common immune-mediated disorders. There is evidence that it is mediated by Th1 and, more recently, Th17 cells. The cytokine pattern, particularly the dominance of TNF-α, implicates the innate immune system in psoriasis pathogenesis. Of the many components of the innate immune system known to be involved in psoriatic lesions, natural killer and natural killer T cells appear to have a unique role. We review the evidence supporting a role for natural killer cells in psoriasis.

Publication types

  • Review

MeSH terms

  • Humans
  • Immunity, Innate
  • Killer Cells, Natural / immunology*
  • Psoriasis / immunology*
  • Psoriasis / pathology
  • Psoriasis / physiopathology*
  • Skin / immunology
  • Skin / pathology