Guasha-induced hepatoprotection in chronic active hepatitis B: a case study

Clin Chim Acta. 2011 Aug 17;412(17-18):1686-8. doi: 10.1016/j.cca.2011.05.009. Epub 2011 May 13.


Background: Heme oxygenase-1 (HO-1) has demonstrated hepatoprotective effect in animal hepatitis models. HO-1 was also reported to be upregulated with Guasha, an ancient therapeutic technique which applies instrument assisted press-stroking to treat many disorders.

Methods: We report a case on the changes of liver function, plasma HO-1 and T-helper (Th) cytokine balance in a chronic active hepatitis B carrier before and after Guasha. The patient presented with increased activities of liver enzymes (ALT and AST), indicating inflammatory damage in liver before Guasha.

Results: Forty-eight hours after receiving Guasha, the patient showed changes in a number of serum markers: a decline of liver enzymes (ALT and AST) indicating reduced chronic inflammation, an elevated plasma HO-1, and a modulation of T-helper (Th)1/Th2 balance.

Conclusions: Guasha was shown to transiently reduce the inflammatory markers of liver injury in human, together with an enhancement of HO-1 which might be responsible for the hepatoprotective action.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Drugs, Chinese Herbal*
  • Hepatitis B, Chronic / pathology
  • Hepatitis B, Chronic / therapy*
  • Humans
  • Liver / drug effects*
  • Male


  • Drugs, Chinese Herbal