Lipin-1γ isoform is a novel lipid droplet-associated protein highly expressed in the brain

FEBS Lett. 2011 Jun 23;585(12):1979-84. doi: 10.1016/j.febslet.2011.05.035. Epub 2011 May 20.


Lipin-1 proteins are phosphatidic acid phosphatases (PAPs) catalyzing the conversion from phosphatidic acid (PA) to diacylglycerol (DG). Two alternative splicing isoforms, lipin-1α and -1β, are localized at different subcellular compartments. A third splicing isoform, lipin-1γ was recently cloned and its subcellular localization is unknown. Here, we demonstrate that lipin-1γ is localized to lipid droplets (LDs), an association mediated by a hydrophobic, lipin-1γ-specific domain. Additional expression of lipin-1γ altered LD morphology without affecting the triacylglycerol (TG) level. In human tissues, lipin-1γ is the main lipin-1 isoform expressed in normal human brain, suggesting a specialized role in regulating brain lipid metabolism.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Brain / metabolism*
  • Humans
  • Lipid Metabolism*
  • Lipids
  • Nuclear Proteins / analysis*
  • Nuclear Proteins / physiology
  • Phosphatidate Phosphatase
  • Protein Isoforms / analysis
  • Protein Isoforms / physiology
  • Triglycerides / analysis


  • Lipids
  • Nuclear Proteins
  • Protein Isoforms
  • Triglycerides
  • LPIN1 protein, human
  • Phosphatidate Phosphatase