Myeloid C-type lectin receptors in pathogen recognition and host defense

Immunity. 2011 May 27;34(5):651-64. doi: 10.1016/j.immuni.2011.05.001.


C-type lectin receptors (CLRs) comprise a heterogeneous group of transmembrane proteins. Many of them are expressed in myeloid cells and signal in response to pathogen-derived or self ligands to initiate or regulate cell activation. Here, we review the properties of myeloid CLRs, highlighting how their signaling function is coordinated with that of other innate receptor families to control immunity to infection.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Adaptive Immunity
  • Animals
  • Humans
  • Immunity, Innate*
  • Lectins, C-Type / immunology*
  • Lectins, C-Type / metabolism
  • Myeloid Cells / immunology*
  • Myeloid Cells / metabolism
  • Signal Transduction


  • Lectins, C-Type