A new twist on the PYRIN Mediterranean coast

Luigi Franchi; Gabriel Núñez

doi:10.1016/j.immuni.2011.05.004

A new twist on the PYRIN Mediterranean coast

Immunity. 2011 May 27;34(5):695-7. doi: 10.1016/j.immuni.2011.05.004.

Authors

Luigi Franchi¹, Gabriel Núñez

Affiliation

¹ Department of Pathology and Comprehensive Cancer Center, University of Michigan Medical School, Ann Arbor, MI 48109, USA.

PMID: 21616439
DOI: 10.1016/j.immuni.2011.05.004

Abstract

Familial Mediterranean fever is caused by mutations of the PYRIN protein. Chae et al. (2011) provide evidence for a ASC protein-dependent pathway of caspase-1 activation in which gain-of-function PYRIN mutations lead to IL-1β cytokine overproduction and inflammatory disease.

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