Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
, 25 (9), 1408-14

Mesenchymal Stromal Cell 'Licensing': A Multistep Process


Mesenchymal Stromal Cell 'Licensing': A Multistep Process

M Krampera. Leukemia.


Many in vitro and in vivo data are available supporting the role of mesenchymal stromal cell (MSC) licensing in the induction of a measurable and effective immune regulation. The failure of some MSC-based protocols for immune modulation in animal models and in human clinical trials may be explained by either lack of a proper licensing by inflammatory microenvironment or wrong timing in MSC administration. Thus, optimization of MSC use for immune-regulating purposes is required to maximize their beneficial effects.

Similar articles

See all similar articles

Cited by 112 articles

See all "Cited by" articles

LinkOut - more resources