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Review
, 25 (9), 1408-14

Mesenchymal Stromal Cell 'Licensing': A Multistep Process

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Review

Mesenchymal Stromal Cell 'Licensing': A Multistep Process

M Krampera. Leukemia.

Abstract

Many in vitro and in vivo data are available supporting the role of mesenchymal stromal cell (MSC) licensing in the induction of a measurable and effective immune regulation. The failure of some MSC-based protocols for immune modulation in animal models and in human clinical trials may be explained by either lack of a proper licensing by inflammatory microenvironment or wrong timing in MSC administration. Thus, optimization of MSC use for immune-regulating purposes is required to maximize their beneficial effects.

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