Fluorinated paramagnetic chelates as potential multi-chromic 19F tracer agents

Chem Commun (Camb). 2011 Jul 7;47(25):7233-5. doi: 10.1039/c1cc11150g. Epub 2011 May 26.

Abstract

A class of potential multi-chromic (19)F imaging tracers is made by pairing metal ions with a fluorinated chelator. All fluorinated metal chelates emit a single (19)F signal. Paramagnetic metal ions shifted the (19)F signal frequency and made the (19)F relaxation rates insensitive toward local chemical environment.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Blood Proteins / chemistry
  • Cattle
  • Chelating Agents / chemistry*
  • Color
  • Fluorine Radioisotopes / chemistry*
  • Halogenation*
  • Humans
  • Magnetic Resonance Spectroscopy
  • Magnetics*

Substances

  • Blood Proteins
  • Chelating Agents
  • Fluorine Radioisotopes