Analysis of the disintegrin-metalloproteinases family reveals ADAM29 and ADAM7 are often mutated in melanoma

Hum Mutat. 2011 Jun;32(6):E2148-75. doi: 10.1002/humu.21477. Epub 2011 Feb 24.


We performed a mutational analysis of the 19 disintegrin-metalloproteinases (ADAMs) genes in human cutaneous metastatic melanoma and identified eight to be somatically mutated in 79 samples, affecting 34% of the melanoma tumors analyzed. Functional analysis of the two frequently mutated ADAM genes, ADAM29 and ADAM7 demonstrated that the mutations affect adhesion of melanoma cells to specific extracellular matrix proteins and in some cases increase their migration ability. This suggests that mutated ADAM genes could play a role in melanoma progression.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • ADAM Proteins / genetics*
  • Adolescent
  • Adult
  • Cell Adhesion / genetics
  • Cell Movement / genetics
  • DNA Mutational Analysis
  • Extracellular Matrix Proteins / genetics
  • Female
  • Humans
  • Male
  • Melanoma / genetics*
  • Melanoma / secondary
  • Membrane Glycoproteins / genetics*
  • Middle Aged
  • Mutation / genetics
  • Neoplasm Metastasis
  • Skin Diseases / genetics*
  • Skin Diseases / pathology


  • Extracellular Matrix Proteins
  • Membrane Glycoproteins
  • ADAM Proteins
  • ADAM29 protein, human
  • ADAM7 protein, human