Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Clinical Trial
. 2012 Feb;26(2):204-7.
doi: 10.1002/ptr.3462. Epub 2011 May 27.

Clinical Assessment of a Supplement of Pycnogenol® and L-arginine in Japanese Patients With Mild to Moderate Erectile Dysfunction

Affiliations
Clinical Trial

Clinical Assessment of a Supplement of Pycnogenol® and L-arginine in Japanese Patients With Mild to Moderate Erectile Dysfunction

Hiromitsu Aoki et al. Phytother Res. .

Abstract

A double-blind parallel group comparison design clinical study was conducted in Japanese patients with mild to moderate erectile dysfunction to investigate the efficacy of a supplement containing Pycnogenol® and L-arginine. Subjects were instructed to take a supplement (Pycnogenol® 60 mg/day, L-arginine 690 mg/day and aspartic acid 552 mg/day) or an identical placebo for 8 weeks, and the results were assessed using the five-item erectile domain (IIEF-5) of the International Index of Erectile Function. Additionally, blood biochemistry, urinalysis and salivary testosterone were measured. Eight weeks of supplement intake improved the total score of the IIEF-5. In particular, a marked improvement was observed in 'hardness of erection' and 'satisfaction with sexual intercourse'. A decrease in blood pressure, aspartate transaminase and γ-glutamyl transpeptidase (γ-GTP), and a slight increase in salivary testosterone were observed in the supplement group. No adverse reactions were observed during the study period. In conclusion, Pycnogenol® in combination with L-arginine as a dietary supplement is effective and safe in Japanese patients with mild to moderate erectile dysfunction.

Similar articles

See all similar articles

Cited by 5 articles

Publication types

Feedback