Proton magnetic resonance spectroscopy of human brain in vivo in the evaluation of multiple sclerosis: assessment of the load of disease

Magn Reson Med. 1990 Apr;14(1):154-9. doi: 10.1002/mrm.1910140115.


Image localized, water-suppressed proton magnetic resonance spectra were obtained from affected brain in patients with multiple sclerosis. In patients with moderate to severe chronic disease, spectra revealed a decreased ratio of N-acetylaspartate to creatine resonance intensities. A normal ratio was obtained from a large recently symptomatic MRI plaque that resolved without sequelae. We propose that the observed metabolite changes can be useful as an index of irreversible CNS injury.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aspartic Acid / analogs & derivatives
  • Aspartic Acid / analysis
  • Brain / metabolism
  • Brain / pathology*
  • Chronic Disease
  • Humans
  • Magnetic Resonance Imaging
  • Magnetic Resonance Spectroscopy* / methods
  • Multiple Sclerosis / diagnosis*
  • Multiple Sclerosis / metabolism
  • Multiple Sclerosis / pathology
  • Protons


  • Protons
  • Aspartic Acid
  • N-acetylaspartate