The cell biology of the unfolded protein response

Gastroenterology. 2011 Jul;141(1):38-41, 41.e1-2. doi: 10.1053/j.gastro.2011.05.018. Epub 2011 May 24.


The unfolded protein response (UPR) is an ensemble of signal transduction pathways that respond to perturbations in the oxidative, pro-folding environment of the endoplasmic reticulum. During the past decade, ongoing research implicated these pathways in maintaining homeostasis of cells and organisms exposed to various stresses. Herein, we highlight recent findings regarding the functional role of the UPR in both normal and pathophysiologic processes.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Apoptosis
  • Autophagy
  • Cell Cycle
  • Endoplasmic Reticulum / metabolism*
  • Endoplasmic Reticulum / virology
  • Energy Metabolism
  • Humans
  • Neoplasms / metabolism
  • Protein Folding*
  • Signal Transduction*
  • Stress, Physiological
  • Unfolded Protein Response*
  • Virus Diseases / metabolism