Role of the CD28 receptor in T-cell activation

Immunol Today. 1990 Jun;11(6):211-6. doi: 10.1016/0167-5699(90)90085-n.


Antigen-specific T-cell activation is initiated through the T-cell receptor. Recent evidence has shown that a number of additional T-cell surface receptors serve to regulate the responses of antigen-activated T cells. One such molecule, CD28, is a member of a heterophilic cell adhesion complex, and is the receptor for the B-cell-restricted B7/BB-1 antigen. As Carl June, Jeffrey Ledbetter, Peter Linsley and Craig Thompson review here, CD28 serves as the surface component of a novel signal transduction pathway that modulates T-cell lymphokine production and increases the resistance of T-cell responses to various immunosuppressive agents.

Publication types

  • Review

MeSH terms

  • Animals
  • Antigens, Differentiation, T-Lymphocyte*
  • CD28 Antigens
  • Humans
  • Lymphocyte Activation
  • Receptors, Antigen, T-Cell*
  • Signal Transduction / immunology
  • T-Lymphocytes / immunology*


  • Antigens, Differentiation, T-Lymphocyte
  • CD28 Antigens
  • Receptors, Antigen, T-Cell