Effect of lithium chloride-induced aversion on appetitive and consummatory behavior

Behav Neurosci. 1990 Jun;104(3):438-40. doi: 10.1037//0735-7044.104.3.438.


The effect of lithium chloride-induced conditioned taste aversions on appetitive and consummatory behavior was determined. Rats were given access to a 0.1% saccharin solution for 15 min either in bottles or by infusion through an intraoral cannula. Bottle-fed rats given postprandial injections of lithium chloride showed greater aversion to saccharin than cannula-fed rats. During extinction, cannula-fed rats gradually recovered to control levels of intake, whereas bottle-fed rats continued to avoid the saccharin. These results suggest that lithium chloride affects appetitive behavior to a greater extent than it affects consummatory behavior.

MeSH terms

  • Animals
  • Appetitive Behavior / drug effects*
  • Association Learning / drug effects
  • Avoidance Learning / drug effects*
  • Chlorides / pharmacology*
  • Conditioning, Classical / drug effects*
  • Consummatory Behavior / drug effects*
  • Extinction, Psychological / drug effects
  • Lithium / pharmacology*
  • Lithium Chloride
  • Male
  • Rats
  • Rats, Inbred Strains
  • Taste / drug effects


  • Chlorides
  • Lithium
  • Lithium Chloride