Abstract
Single nucleotide polymorphisms in human pro- and anti-inflammatory genes, including IL1RN VNTR (rs315952), IL1A 4845G>T (rs17561), L1B-511C>T (rs16944), IL6-174G>C (rs1800795), IL10-1082 A>G (rs 1800896) and TNFα-308G>A (rs1800629) and their impact on multiple sclerosis risk and disease progression in a Polish population were investigated. Increased risk of MS was found for IL6-174 CC homozygotes (OR, 2.88; p<0.00001). In turn, IL1A 4845 TT genotype determined earlier appearance of MS onset whereas IL1B-511 TT genotype was associated with later occurrence of MS but faster disability progression.
Copyright © 2011 Elsevier B.V. All rights reserved.
MeSH terms
-
Adult
-
Disease Progression
-
Female
-
Humans
-
Interleukin 1 Receptor Antagonist Protein / genetics*
-
Interleukin-10 / genetics*
-
Interleukin-1alpha / genetics*
-
Interleukin-1beta / genetics*
-
Interleukin-6 / genetics*
-
Male
-
Middle Aged
-
Multiple Sclerosis / diagnosis
-
Multiple Sclerosis / epidemiology
-
Multiple Sclerosis / genetics*
-
Poland / epidemiology
-
Polymorphism, Genetic / genetics*
-
Population Surveillance / methods
-
Risk Factors
-
Time Factors
-
Tumor Necrosis Factor-alpha / genetics*
Substances
-
IL1RN protein, human
-
Interleukin 1 Receptor Antagonist Protein
-
Interleukin-1alpha
-
Interleukin-1beta
-
Interleukin-6
-
Tumor Necrosis Factor-alpha
-
Interleukin-10