Association of IL1A, IL1B, ILRN, IL6, IL10 and TNF-α polymorphisms with risk and clinical course of multiple sclerosis in a Polish population

J Neuroimmunol. 2011 Jul;236(1-2):87-92. doi: 10.1016/j.jneuroim.2011.04.014. Epub 2011 May 31.

Abstract

Single nucleotide polymorphisms in human pro- and anti-inflammatory genes, including IL1RN VNTR (rs315952), IL1A 4845G>T (rs17561), L1B-511C>T (rs16944), IL6-174G>C (rs1800795), IL10-1082 A>G (rs 1800896) and TNFα-308G>A (rs1800629) and their impact on multiple sclerosis risk and disease progression in a Polish population were investigated. Increased risk of MS was found for IL6-174 CC homozygotes (OR, 2.88; p<0.00001). In turn, IL1A 4845 TT genotype determined earlier appearance of MS onset whereas IL1B-511 TT genotype was associated with later occurrence of MS but faster disability progression.

Publication types

  • Comparative Study

MeSH terms

  • Adult
  • Disease Progression
  • Female
  • Humans
  • Interleukin 1 Receptor Antagonist Protein / genetics*
  • Interleukin-10 / genetics*
  • Interleukin-1alpha / genetics*
  • Interleukin-1beta / genetics*
  • Interleukin-6 / genetics*
  • Male
  • Middle Aged
  • Multiple Sclerosis / diagnosis
  • Multiple Sclerosis / epidemiology
  • Multiple Sclerosis / genetics*
  • Poland / epidemiology
  • Polymorphism, Genetic / genetics*
  • Population Surveillance / methods
  • Risk Factors
  • Time Factors
  • Tumor Necrosis Factor-alpha / genetics*

Substances

  • IL1RN protein, human
  • Interleukin 1 Receptor Antagonist Protein
  • Interleukin-1alpha
  • Interleukin-1beta
  • Interleukin-6
  • Tumor Necrosis Factor-alpha
  • Interleukin-10