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Comparative Study
. 2011 Jul;236(1-2):87-92.
doi: 10.1016/j.jneuroim.2011.04.014. Epub 2011 May 31.

Association of IL1A, IL1B, ILRN, IL6, IL10 and TNF-α Polymorphisms With Risk and Clinical Course of Multiple Sclerosis in a Polish Population

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Comparative Study

Association of IL1A, IL1B, ILRN, IL6, IL10 and TNF-α Polymorphisms With Risk and Clinical Course of Multiple Sclerosis in a Polish Population

Dagmara Mirowska-Guzel et al. J Neuroimmunol. .

Abstract

Single nucleotide polymorphisms in human pro- and anti-inflammatory genes, including IL1RN VNTR (rs315952), IL1A 4845G>T (rs17561), L1B-511C>T (rs16944), IL6-174G>C (rs1800795), IL10-1082 A>G (rs 1800896) and TNFα-308G>A (rs1800629) and their impact on multiple sclerosis risk and disease progression in a Polish population were investigated. Increased risk of MS was found for IL6-174 CC homozygotes (OR, 2.88; p<0.00001). In turn, IL1A 4845 TT genotype determined earlier appearance of MS onset whereas IL1B-511 TT genotype was associated with later occurrence of MS but faster disability progression.

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