Suppressing allergic immune responses

Front Biosci (Elite Ed). 2011 Jun 1;3:864-70.

Abstract

While most studies are devoted to understanding the activation of cytokine gene transcription, few studies have focused on the silencing of cytokine gene transcription. This review will focus on the molecular mechanisms by which Th1-promoting factors downregulate the Il4 gene.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Cell Differentiation / immunology
  • Chromatin / chemistry
  • Cytokines / genetics
  • Cytokines / physiology
  • Humans
  • Hypersensitivity / immunology*
  • Hypersensitivity / physiopathology
  • Hypersensitivity / prevention & control
  • Hypersensitivity / therapy
  • Immunotherapy
  • STAT Transcription Factors / physiology
  • T-Lymphocytes, Regulatory / immunology
  • T-Lymphocytes, Regulatory / metabolism
  • Th2 Cells / cytology

Substances

  • Chromatin
  • Cytokines
  • STAT Transcription Factors