C-Myb function in the vessel wall

Front Biosci (Elite Ed). 2011 Jun 1;3:968-77. doi: 10.2741/e302.

Abstract

C-Myb is a DNA-binding transcription factor that functions in apoptosis, proliferation and differentiation. The role of c-Myb in vascular injury has been investigated previously both in vitro and in vivo, where knock-down of c-Myb is known to lead to a reduction in proliferation and an increase in apoptosis of vascular smooth muscle cells (VSMCs). Reduction of c-Myb activity has also been shown to decrease neointimal formation in vivo, by reducing VSMC proliferation. In contrast, over-expression of c-Myb in vivo leads to increased survival rates in certain cell types. This review will look mainly at studies investigating c-Myb function in the vasculature, and evidence of signalling interactions which may be considered with regard to c-Myb as a possible target in the treatment of vasculoproliferative diseases.

Publication types

  • Review

MeSH terms

  • Animals
  • Blood Vessels / physiology*
  • Endothelium, Vascular / physiology*
  • Hematopoiesis
  • Humans
  • Proto-Oncogene Proteins c-myb / physiology*
  • Signal Transduction
  • Tunica Intima / physiology*

Substances

  • Proto-Oncogene Proteins c-myb