RAS and Hedgehog--partners in crime

Front Biosci (Landmark Ed). 2011 Jun 1;16:2259-70. doi: 10.2741/3852.


Both RAS and Hedgehog (HH) pathway activation can be found in approximately one third of all cancers. In many cases, this activation occurs in the same tumor types, suggesting a positive impact of a simultaneous activation of RAS and HH on tumor development. This review aims to summarize the current knowledge about the molecular and functional crosstalk of RAS and HH signaling in the development of hyperproliferative disease.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Cell Transformation, Neoplastic / genetics
  • Genes, ras
  • Hedgehog Proteins / genetics
  • Hedgehog Proteins / physiology*
  • Humans
  • Models, Biological
  • Mutation
  • Neoplasms / etiology
  • Neoplasms / genetics
  • Neoplasms / physiopathology*
  • Protein Interaction Mapping
  • Signal Transduction
  • ras Proteins / genetics
  • ras Proteins / physiology*


  • Hedgehog Proteins
  • ras Proteins