WT1/EGR1-mediated control of STIM1 expression and function in cancer cells

Front Biosci (Landmark Ed). 2011 Jun 1;16:2402-15. doi: 10.2741/3862.

Abstract

There have been numerous publications linking Ca(2+) signaling and cancer, however, a clear explanation for this link has remained elusive. We recently identified the oncogenes/tumor suppressors Wilms Tumor Suppressor 1 (WT1) and Early Growth Response 1 (EGR1) as regulators of the expression of STIM1, an essential regulator of Ca(2+) entry in non-excitable cells. The current review focuses on the literature defining both differential Ca(2+) signaling and WT1/EGR1 expression patterns in 6 specific cancer subtypes: Acute Myeloid Leukemia, Wilms Tumor, breast cancer, ovarian cancer, glioblastoma and prostate cancer. For each tumor-type, we have assessed how specific changes in WT1 and EGR1 expression might contribute to aberrant Ca(2+) homeostasis as well as the therapeutic potential of these observations.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Brain Neoplasms / genetics
  • Brain Neoplasms / metabolism
  • Breast Neoplasms / genetics
  • Breast Neoplasms / metabolism
  • Calcium Signaling
  • Early Growth Response Protein 1 / genetics
  • Early Growth Response Protein 1 / metabolism*
  • Female
  • Gene Expression Regulation, Neoplastic
  • Genes, Tumor Suppressor
  • Genes, Wilms Tumor
  • Glioblastoma / genetics
  • Glioblastoma / metabolism
  • Humans
  • Leukemia, Myeloid, Acute / genetics
  • Leukemia, Myeloid, Acute / metabolism
  • Male
  • Membrane Proteins / genetics
  • Membrane Proteins / metabolism*
  • Models, Biological
  • Neoplasm Proteins / genetics
  • Neoplasm Proteins / metabolism*
  • Neoplasms / genetics
  • Neoplasms / metabolism*
  • Oncogenes
  • Ovarian Neoplasms / genetics
  • Ovarian Neoplasms / metabolism
  • Prostatic Neoplasms / genetics
  • Prostatic Neoplasms / metabolism
  • Proto-Oncogene Proteins c-bcl-2 / metabolism
  • Stromal Interaction Molecule 1
  • Transient Receptor Potential Channels / metabolism
  • WT1 Proteins / metabolism*
  • Wilms Tumor / genetics
  • Wilms Tumor / metabolism

Substances

  • EGR1 protein, human
  • Early Growth Response Protein 1
  • Membrane Proteins
  • Neoplasm Proteins
  • Proto-Oncogene Proteins c-bcl-2
  • STIM1 protein, human
  • Stromal Interaction Molecule 1
  • Transient Receptor Potential Channels
  • WT1 Proteins