Crosstalk between viruses and PML nuclear bodies: a network-based approach

Front Biosci (Landmark Ed). 2011 Jun 1;16:2910-20. doi: 10.2741/3889.

Abstract

Due to the recent advances in instrumental and scientific methods, cell biology data are generated with increasing speed and quantity. One of these fast developing fields is the crosstalk between promyelocytic leukemia protein nuclear bodies (PML-NBs) and viruses. PML-NBs are dynamic nuclear protein aggregates which are targeted by entire viral particles, viral proteins or viral nucleic acids. Their possible anti-viral properties motivated researchers to investigate the interaction between PML-NBs and viruses in depth. Based on extensive literature data mining, we created a comprehensive PML-NB/virus crosstalk Cytoscape network, which groups not only the most common relations but also less well described findings. The network is easy to navigate and provides a biologically relevant overview which can help finding interesting case studies.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Humans
  • Inclusion Bodies, Viral / metabolism*
  • Inclusion Bodies, Viral / virology*
  • Intranuclear Inclusion Bodies / metabolism*
  • Intranuclear Inclusion Bodies / virology*
  • Leukemia, Promyelocytic, Acute / metabolism*
  • Leukemia, Promyelocytic, Acute / virology*
  • Models, Biological
  • Neoplasm Proteins / metabolism
  • Nucleic Acids / metabolism
  • Viral Proteins / metabolism

Substances

  • Neoplasm Proteins
  • Nucleic Acids
  • Viral Proteins