Bone Phenotypes of P2 Receptor Knockout Mice

Front Biosci (Schol Ed). 2011 Jun 1;3:1038-46. doi: 10.2741/208.

Abstract

The action of extracellular nucleotides is mediated by ionotropic P2X receptors and G-protein coupled P2Y receptors. The human genome contains 7 P2X and 8 P2Y receptor genes. Knockout mice strains are available for most of them. As their phenotypic analysis is progressing, bone abnormalities have been observed in an impressive number of these mice: distinct abnormalities in P2X7-/- mice, depending on the gene targeting construct and the genetic background, decreased bone mass in P2Y1-/- mice, increased bone mass in P2Y2-/- mice, decreased bone resorption in P2Y6-/- mice, decreased bone formation and bone resorption in P2Y13-/- mice. These findings demonstrate the unexpected importance of extracellular nucleotide signalling in the regulation of bone metabolism via multiple P2 receptors and distinct mechanisms involving both osteoblasts and osteoclasts.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Bone Density / genetics
  • Bone Resorption / genetics
  • Bone and Bones / abnormalities*
  • Bone and Bones / metabolism*
  • Extracellular Space / metabolism
  • Mice
  • Mice, Knockout
  • Nucleotides / metabolism
  • Phenotype*
  • Receptors, Purinergic P2 / genetics*
  • Signal Transduction / genetics*

Substances

  • Nucleotides
  • Receptors, Purinergic P2