The Function of Histamine Receptor H4R in the Brain Revealed by Interaction Partners

Front Biosci (Schol Ed). 2011 Jun 1;3:1058-66. doi: 10.2741/210.


The histamine H4 receptor is mainly expressed in haematopoietic cells, hence is linked to inflammatory and immune system conditions. It has been recently discovered that the receptor is expressed also in the mammalian central nervous system (CNS), but its role in the brain remains unclear. We address the potential functions of the histamine H4 receptor in the human brain using a 'guilty by association' logic, by close examination of protein-protein functional associations networks in the human proteome.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Brain / metabolism*
  • Humans
  • Protein Interaction Mapping / methods*
  • Proteomics / methods*
  • Receptors, G-Protein-Coupled / metabolism*
  • Receptors, Histamine / metabolism*
  • Receptors, Histamine H3 / metabolism
  • Receptors, Histamine H4


  • HRH4 protein, human
  • Receptors, G-Protein-Coupled
  • Receptors, Histamine
  • Receptors, Histamine H3
  • Receptors, Histamine H4