Electrochemical and optical biosensors based on nanomaterials and nanostructures: a review

Front Biosci (Schol Ed). 2011 Jun 1;3:1308-31. doi: 10.2741/228.


Nanomaterials and nanostructures exhibit unique size-tunable and shape-dependent physicochemical properties that are different from those of bulk materials. Advances of nanomaterials and nanostructures open a new door to develop various novel biosensors. The present work has reviewed the recent progress in electrochemical, surface plasmon resonance (SPR), surface-enhanced Raman scattering (SERS) and fluorescent biosensors based on nanomaterials and nanostructures. An emphasis is put on the research that demonstrates how the performance of biosensors such as the limit of detection, sensitivity and selectivity is improved by the use of nanomaterials and nanostructures.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Review

MeSH terms

  • Adsorption
  • Biosensing Techniques / instrumentation
  • Biosensing Techniques / methods*
  • Electrochemical Techniques / instrumentation
  • Electrochemical Techniques / methods*
  • Fluorescence
  • Immunoassay / methods
  • Models, Molecular*
  • Molecular Structure
  • Nanostructures / chemistry*
  • Spectrum Analysis, Raman / instrumentation
  • Spectrum Analysis, Raman / methods*
  • Surface Plasmon Resonance / instrumentation
  • Surface Plasmon Resonance / methods*