Cancer immunology and colorectal cancer recurrence

Front Biosci (Schol Ed). 2011 Jun 1;3:1421-31. doi: 10.2741/233.

Abstract

The recurrence of a cancer - local or distant (metastasis) - is manifested by the persistence of cancer cells in the organism after the ablation of the primary lesion, an ineffective anticancer immune response, and by the activity of biological/immunological factors that can stimulate and sustain its development. This review focuses on colorectal carcinoma and discusses some aspects of cancer immunology regarding cancer development and its recurrence. It is addressed also to the clinician to provide new insights helpful for designing better therapeutic strategies and patient's follow up. Therapeutic approaches used during and after surgical treatments, found capable of modulating immunity (differently affecting disease outcome), will also be described.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Colorectal Neoplasms / immunology*
  • Colorectal Neoplasms / physiopathology
  • Colorectal Neoplasms / therapy*
  • Humans
  • Immunotherapy / methods*
  • Inflammation / immunology*
  • NF-kappa B / metabolism
  • Neoplasm Metastasis / immunology
  • Neoplasm Metastasis / prevention & control*
  • Neoplasm Recurrence, Local / immunology
  • Neoplasm Recurrence, Local / prevention & control*
  • STAT3 Transcription Factor / metabolism

Substances

  • NF-kappa B
  • STAT3 Transcription Factor
  • STAT3 protein, human