Alternatively spliced tissue factor pathway inhibitor: functional implications

Front Biosci (Schol Ed). 2011 Jun 1;3:1457-62. doi: 10.2741/236.

Abstract

Tissue factor pathway inhibitor (TFPI) is a factor Xa dependent inhibitor of tissue factor initiated blood coagulation. In recent years several alternatively spliced forms of TFPI have been identified. These alternatively spliced forms have different C-terminal regions and have different mechanisms for association with cell surfaces. They are differentially expressed in human and mouse tissues and may have distinct physiological functions.

Publication types

  • Comparative Study
  • Review

MeSH terms

  • Alternative Splicing / genetics*
  • Amino Acid Sequence
  • Animals
  • Evolution, Molecular*
  • Factor Xa Inhibitors*
  • Humans
  • Lipoproteins / genetics*
  • Lipoproteins / metabolism*
  • Mice
  • Models, Molecular*
  • Molecular Sequence Data
  • Species Specificity

Substances

  • Factor Xa Inhibitors
  • Lipoproteins
  • lipoprotein-associated coagulation inhibitor