Immunologic mapping of glycomes: implications for cancer diagnosis and therapy

Front Biosci (Schol Ed). 2011 Jun 1;3:1520-32. doi: 10.2741/242.

Abstract

Cancer associated glycoconjugates are important biomarkers, as exemplified by globo-H, CA125, CA15.3 and CA27.29. However, the exact chemical structures of many such biomarkers remain unknown because of technological limitations. In this article, we propose the "immunologic mapping" of cancer glycomes based on specific immune recognition of glycan structures, which can be hypothesized theoretically, produced chemically, and examined biologically by immuno-assays. Immunologic mapping of glycans not only provides a unique perspective on cancer glycomes, but also may lead to the invention of powerful reagents for diagnosis and therapy.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Adaptive Immunity / immunology*
  • Antigens, Surface / metabolism*
  • Epitopes / immunology
  • Epitopes / metabolism
  • Galectins / metabolism
  • Glycoconjugates / immunology
  • Glycoconjugates / metabolism*
  • Glycomics / methods*
  • Humans
  • Lectins / metabolism
  • Lectins, C-Type / metabolism
  • Mass Spectrometry / methods
  • Neoplasms / diagnosis*
  • Neoplasms / drug therapy*
  • Polysaccharides / metabolism*
  • Receptors, Antigen, T-Cell / metabolism
  • Sialic Acid Binding Immunoglobulin-like Lectins
  • Signal Transduction / immunology*

Substances

  • Antigens, Surface
  • Epitopes
  • Galectins
  • Glycoconjugates
  • Lectins
  • Lectins, C-Type
  • Polysaccharides
  • Receptors, Antigen, T-Cell
  • Sialic Acid Binding Immunoglobulin-like Lectins