Efficient bifunctional gallium-68 chelators for positron emission tomography: tris(hydroxypyridinone) ligands

Chem Commun (Camb). 2011 Jul 7;47(25):7068-70. doi: 10.1039/c1cc12123e. Epub 2011 May 27.

Abstract

A new tripodal tris(hydroxypyridinone) bifunctional chelator for gallium allows easy production of (68)Ga-labelled proteins rapidly under mild conditions in high yields at exceptionally high specific activity and low concentration.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Chelating Agents / chemistry*
  • Cross-Linking Reagents / chemistry*
  • Gallium Radioisotopes
  • Humans
  • Ligands
  • Mice
  • Positron-Emission Tomography / methods*
  • Pyridones / chemistry*
  • Synaptotagmin I / chemistry

Substances

  • Chelating Agents
  • Cross-Linking Reagents
  • Gallium Radioisotopes
  • Ligands
  • Pyridones
  • Synaptotagmin I