Stromal cells do not share KRAS mutations that the epithelial component harbors in colorectal carcinomas

Cancer Lett. 2011 Sep 1;308(1):118-21. doi: 10.1016/j.canlet.2011.04.021. Epub 2011 May 31.


Epithelia and stroma are the main components of carcinomas that have impact on carcinogenesis. Many of the genetic changes harboring in the epithelia may possibly be seen in stromal cells during neoplastic transformation. We intended to investigate weather KRAS mutations are shared by the stromal cells in colorectal adenocarcinomas. Forty cases with KRAS mutation were studied. Glandular/epithelial and the stromal components of each primary tumor were collected and KRAS mutation analysis was performed. None of the cases revealed KRAS mutations in stromal integral. We concluded that stromal cells in colorectal carcinoma do not share KRAS mutations that the epithelial component harbors.

MeSH terms

  • Aged
  • Colorectal Neoplasms / genetics*
  • Colorectal Neoplasms / pathology*
  • Female
  • Humans
  • Male
  • Middle Aged
  • Mutation*
  • Proto-Oncogene Proteins / genetics*
  • Proto-Oncogene Proteins p21(ras)
  • Stromal Cells / pathology
  • Stromal Cells / physiology
  • ras Proteins / genetics*


  • KRAS protein, human
  • Proto-Oncogene Proteins
  • Proto-Oncogene Proteins p21(ras)
  • ras Proteins