Uric acid as a cardiometabolic risk factor: to be or not to be

Contrib Nephrol. 2011;171:62-67. doi: 10.1159/000327160. Epub 2011 May 23.


Most authorities do not consider hyperuricemia to be an important risk factor for cardiovascular or renal disease. However, emerging data suggest that elevated uric acid (UA) is actually one of the most important factors for cardiovascular disease and that it also plays a significant role in the development of renal disease and metabolic syndrome. In the current review, we will analyze the role of cardiometabolic disorders related to UA and briefly explain the pathogenetic mechanisms behind these relationships.

Publication types

  • Review

MeSH terms

  • Cardiovascular Diseases / etiology*
  • Humans
  • Hypertension / etiology
  • Hyperuricemia / complications*
  • Kidney Diseases / etiology
  • Metabolic Syndrome / etiology*
  • Risk Factors
  • Uric Acid / blood*


  • Uric Acid