Formal total synthesis of (-)-oseltamivir phosphate

Takanori Tanaka; Qitao Tan; Hiromu Kawakubo; Masahiko Hayashi

doi:10.1021/jo200698g

Formal total synthesis of (-)-oseltamivir phosphate

J Org Chem. 2011 Jul 1;76(13):5477-9. doi: 10.1021/jo200698g. Epub 2011 Jun 9.

Authors

Takanori Tanaka¹, Qitao Tan, Hiromu Kawakubo, Masahiko Hayashi

Affiliation

¹ Department of Chemistry, Graduate School of Science, Kobe University, Nada, Kobe 657-501, Japan.

PMID: 21627156
DOI: 10.1021/jo200698g

Abstract

An asymmetric synthesis of chiral intermediate 3 for (-)-oseltamivir phosphate has been accomplished from chiral building block 1, which was prepared by catalytic asymmetric synthesis.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Molecular Conformation
Oseltamivir / chemical synthesis*
Oseltamivir / chemistry
Phosphates / chemical synthesis*
Phosphates / chemistry
Stereoisomerism

Substances

Phosphates
Oseltamivir