Transcriptional Regulation of ompF2, an ompF Paralogue, in Yersinia Pestis

Can J Microbiol. 2011 Jun;57(6):468-75. doi: 10.1139/w11-028. Epub 2011 May 31.


A regulatory circuit composed of three porins (OmpF, OmpC, and OmpX) and two transcriptional regulators (OmpR and CRP) has previously been characterized in Yersinia pestis . In this follow-up study, OmpF2, an OmpF paralogue, was integrated into this regulatory circuit. Only basal expression was detected for ompF2 in the wild-type strain under different osmotic conditions. The ompF2 transcription was dramatically enhanced with increasing medium osmolarity in the ompR null mutant background. The CRP regulator had no regulatory effect on ompF2 under the growth conditions tested.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Bacterial Proteins / genetics
  • Bacterial Proteins / metabolism*
  • Cyclic AMP Receptor Protein / metabolism
  • Gene Expression Regulation, Bacterial
  • Gene Regulatory Networks
  • Mutation
  • Porins / genetics
  • Porins / metabolism*
  • Promoter Regions, Genetic
  • RNA, Bacterial / genetics
  • Transcription, Genetic
  • Yersinia pestis / genetics*
  • Yersinia pestis / metabolism


  • Bacterial Proteins
  • Cyclic AMP Receptor Protein
  • OmpF protein
  • Porins
  • RNA, Bacterial