Innate immune system gene polymorphisms in maternal and child genotype and risk of preterm delivery

J Matern Fetal Neonatal Med. 2012 Mar;25(3):240-7. doi: 10.3109/14767058.2011.569614. Epub 2011 Jun 1.


Objective: There is little information about the combination of genetic variability in pregnant women and their children in relation to the risk of preterm delivery (PTD). In a sub-cohort of 487 non-Hispanic white and 288 African-American mother/child pairs, the Pregnancy Outcomes and Community Health Study assessed 10 functional polymorphisms in 9 genes involved in innate immune function.

Methods: Race-stratified weighted logistic regression models were used to calculate odds ratios for genotype and PTD/PTD subtypes. Polymorphisms significantly associated with PTD/PTD subtypes were tested for mother/child genotype interactions.

Results: Three maternal polymorphisms (IL-1 receptor antagonist intron two repeat (IL-1RN), matrix metalloproteinase- -C1562T, and TNF receptor two M196R (TNFR2)) and three child polymorphisms (IL1-RN, tumor necrosis factor-alpha -G308A, and TNFR2) were associated with PTD, but associations varied by PTD subtype and race. Two interactions were detected for maternal and child genotype. Among non-Hispanic white women, the odds of PTD was higher when both mother and child carried the IL-1RN allele two (additive interaction p < 0.05). Among African-American women, the odds of PTD were higher when both mother and child carried the TNFR2 R allele (multiplicative interaction p < 0.05).

Conclusion: These results highlight the importance of assessing both maternal and child genotype in relation to PTD risk.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adult
  • African Americans / genetics
  • European Continental Ancestry Group / genetics
  • Female
  • Follow-Up Studies
  • Humans
  • Immunity, Innate / genetics*
  • Infant, Newborn
  • Infant, Premature
  • Logistic Models
  • Male
  • Obstetric Labor, Premature / ethnology
  • Obstetric Labor, Premature / genetics*
  • Polymorphism, Genetic*
  • Pregnancy
  • Premature Birth / genetics*
  • Risk
  • Risk Factors
  • Surveys and Questionnaires
  • Young Adult