Bcl-2 interaction with the inositol 1,4,5-trisphosphate receptor: role in Ca(2+) signaling and disease

Cell Calcium. 2011 Sep;50(3):234-41. doi: 10.1016/j.ceca.2011.05.011. Epub 2011 May 31.


The Bcl-2 protein, best known for its ability to inhibit apoptosis, interacts with the inositol 1,4,5-trisphosphate receptor (IP(3)R) Ca(2+) channel to regulate IP(3)-mediated Ca(2+) release from the endoplasmic reticulum. This review summarizes the current state of knowledge regarding the interaction of Bcl-2, and also its homologue Bcl-xl, with the IP(3)R and how these interactions regulate Ca(2+) signaling. The dual role of these interactions in promoting prosurvival Ca(2+) signals, while at the same time inhibiting proapoptotic Ca(2+) signals, is discussed. Moreover, this review will elucidate the recently recognized importance of the Bcl-2-IP(3)R interaction in human disease.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Bipolar Disorder / metabolism*
  • Calcium Signaling / physiology*
  • Cell Death
  • Endoplasmic Reticulum / metabolism
  • Humans
  • Inositol 1,4,5-Trisphosphate Receptors / metabolism*
  • Leukemia, Lymphocytic, Chronic, B-Cell / metabolism*
  • Proto-Oncogene Proteins c-bcl-2 / metabolism*


  • Inositol 1,4,5-Trisphosphate Receptors
  • Proto-Oncogene Proteins c-bcl-2