Solid phase combinatorial synthesis of a xanthone library using click chemistry and its application to an embryonic stem cell probe

Chem Commun (Camb). 2011 Jul 14;47(26):7488-90. doi: 10.1039/c1cc11962a. Epub 2011 Jun 1.

Abstract

We report the first solid phase synthesis of a xanthone library CX and its application to embryonic stem cell probe development. The CX library was further derivatised with an activated ester resin to provide an acetylated CX (CXAC) library. Screening of these libraries led to the discovery of a novel fluorescent mESC probe, CDb8.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Click Chemistry*
  • Combinatorial Chemistry Techniques / methods*
  • Embryonic Stem Cells / metabolism*
  • Fluorescent Dyes / chemical synthesis
  • Fluorescent Dyes / chemistry
  • Fluorescent Dyes / metabolism
  • Mice
  • Small Molecule Libraries / chemical synthesis
  • Small Molecule Libraries / chemistry
  • Small Molecule Libraries / metabolism
  • Xanthones / chemical synthesis*
  • Xanthones / chemistry
  • Xanthones / metabolism*

Substances

  • Fluorescent Dyes
  • Small Molecule Libraries
  • Xanthones
  • xanthone