The role of nuclear factor κB in the interferon response

J Interferon Cytokine Res. 2011 Jul;31(7):553-9. doi: 10.1089/jir.2011.0028. Epub 2011 Jun 1.


The nuclear factor κB (NF-κB) transcription factor regulates the expression of genes involved in cell survival and immune responses. We have identified a novel interferon (IFN)-activated signaling pathway that leads to NF-κB activation and demonstrate that a subset of IFN-stimulated genes and microRNAs that play key roles in cellular response to IFN is regulated by NF-κB. This review focuses on the IFN-induced NF-κB activation pathway and the role of NF-κB in the expression of IFN-induced coding and noncoding genes, antiviral activity and apoptosis, and the therapeutic application of IFN in cancer and infectious disease.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Apoptosis / immunology
  • Bacterial Infections / drug therapy*
  • Bacterial Infections / immunology
  • Gene Expression Regulation / immunology
  • Humans
  • Immunity, Cellular
  • Interferons / genetics
  • Interferons / immunology
  • Interferons / metabolism
  • Interferons / therapeutic use*
  • NF-kappa B / genetics
  • NF-kappa B / metabolism*
  • Neoplasms / drug therapy*
  • Neoplasms / immunology
  • Signal Transduction / immunology
  • Transcriptional Activation / immunology
  • Virus Diseases / drug therapy*
  • Virus Diseases / immunology


  • NF-kappa B
  • Interferons